Silicon Oxycarbide Nanoparticles as New Drug Delivery Materials for Infectious Disease Treatments

This paper has analyzed the surface energy presented by different biomaterials type Ormosil based on the system TEOS – PDMS – TiO2 – CaO and how this energy influences the capacity of formation of Hidroxyapatite on its surface. Surface energy has been determined by inverse gas-solid chromatography to infinite dilution and the dispersive and acid-base constants have been calculated depending on the content in TiO2 and CaO. The surface fractal constant and the specific surface and distribution of pore volumes have also been determined. The obtained materials presented specific surface areas between 200 and 500 m2.g-1, with fractality between 2.13 and 2.41, dispersive components between 34 and 46 mJ.m-2, acidity between 1.2 and 1.6, and basicity between 0.9 and 1.9.

The formation of Hidroxiapatito has been verified by X-ray diffraction and scanning electron microscopy.
The work has shown how bioactivity does not depend on the specific surface or on the surface porosity or nanorrugosidad (fractality), but it depends on the polar character and more specifically on the acid/base ratio. In order for the material to be bioactive, it must present high polarity and low acid/base ratio